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, which initializes a new exception object with a specified error message and inner exception.

Exception (SerializationInfo, StreamingContext) , which is a protected constructor that initializes a new exception object from serialized data. You should implement this constructor if you've chosen to make your exception object serializable.

protected

The following example illustrates the use of a custom exception class. It defines a NotPrimeException exception that is thrown when a client tries to retrieve a sequence of prime numbers by specifying a starting number that is not prime. The exception defines a new property, NonPrime , that returns the non-prime number that caused the exception. Besides implementing a protected parameterless constructor and a constructor with SerializationInfo and StreamingContext parameters for serialization, the NotPrimeException class defines three additional constructors to support the NonPrime property. Each constructor calls a base class constructor in addition to preserving the value of the non-prime number. The NotPrimeException class is also marked with the SerializableAttribute attribute.

The PrimeNumberGenerator class shown in the following example uses the Sieve of Eratosthenes to calculate the sequence of prime numbers from 2 to a limit specified by the client in the call to its class constructor. The GetPrimesFrom method returns all prime numbers that are greater than or equal to a specified lower limit, but throws a NotPrimeException if that lower limit is not a prime number.

The following example makes two calls to the GetPrimesFrom method with non-prime numbers, one of which crosses application domain boundaries. In both cases, the exception is thrown and successfully handled in client code.

Windows Runtime and .NET Framework 4.5.1

In .NET for Windows 8.x Store apps for Windows 8, some exception information is typically lost when an exception is propagated through non-.NET Framework stack frames. Starting with the .NET Framework 4.5.1 and Windows 8.1, the common language runtime continues to use the original Exception object that was thrown unless that exception was modified in a non-.NET Framework stack frame.

Examples

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Physicians: They're the people we call when the contractions come every five minutes. We rush to them for broken arms, and we make appointments when we find irregular freckles. We come to them with coughs and colds and when we suspect that mom might be losing her memory or that dad's heart is working too hard. They're obstetricians and gynecologists, ER doctors, dermatologists, primary care providers, neurologists and cardiologists.There are two main types of physicians: Medical Doctors (M.D.s) and Doctors of Osteopathic Medicine (D.O.s). Both diagnose and treat patients for a range of medical issues, although a D.O. might also specialize in preventive medicine and holistic patient care. Within these categories, there are a host of specialties, from radiology to allergy and immunology, plastic surgery to urology, pediatric to geriatric.Over the last couple decades, there have been huge advancements in the field of medicine making patient care better, says Robert M. Wah , president of the American Medical Association who teaches in the District of Columbia metro area and is a board-certified obstetrician and gynecologist specializing in reproductive endocrinology and infertility. But he also says that physicians today face challenges too. "There are a lot of nonmedical people intruding into [a physician's] exam room," he says, citing legislators who make laws about what can be said and done and lawyers who threaten medical liability.Still, he says that medicine is a career that offers great opportunities and potential. The Bureau of Labor Statistics projects that employment for physicians will increasea higher-than-average17 percent from 2016 to 2026, which translates to about 8,400 job openings. An aging population with increasing health concerns and health reform that will lead more Americans to health care services is driving this demand.

$196,380 Median Salary
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A physician's average salary varies. In 2016, a general internist made a median salary of $196,380, according to the BLS. The highest-paid in the profession earned upward of $208,000, while the lowest-paid made $60,080.

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June 13, 2018 Article
Eduardo De Pablo-Fernandez , Raph Goldacre , Julia Pakpoor , Alastair J. Noyce , Thomas T. Warner
First published June 13, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005771
Eduardo De Pablo-Fernandez
From the Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neurosciences (E.D.P.-F., A.J.N., T.T.W.), and Queen Square Brain Bank for Neurological Disorders (E.D.P.-F., T.T.W.), UCL Institute of Neurology, London; Unit of Health-Care Epidemiology (R.G., J.P.), Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford; and Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK.
Raph Goldacre
From the Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neurosciences (E.D.P.-F., A.J.N., T.T.W.), and Queen Square Brain Bank for Neurological Disorders (E.D.P.-F., T.T.W.), UCL Institute of Neurology, London; Unit of Health-Care Epidemiology (R.G., J.P.), Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford; and Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK.
Julia Pakpoor
From the Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neurosciences (E.D.P.-F., A.J.N., T.T.W.), and Queen Square Brain Bank for Neurological Disorders (E.D.P.-F., T.T.W.), UCL Institute of Neurology, London; Unit of Health-Care Epidemiology (R.G., J.P.), Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford; and Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK.
Alastair J. Noyce
From the Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neurosciences (E.D.P.-F., A.J.N., T.T.W.), and Queen Square Brain Bank for Neurological Disorders (E.D.P.-F., T.T.W.), UCL Institute of Neurology, London; Unit of Health-Care Epidemiology (R.G., J.P.), Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford; and Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK.
Thomas T. Warner
From the Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neurosciences (E.D.P.-F., A.J.N., T.T.W.), and Queen Square Brain Bank for Neurological Disorders (E.D.P.-F., T.T.W.), UCL Institute of Neurology, London; Unit of Health-Care Epidemiology (R.G., J.P.), Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford; and Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK.
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Objective To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD).

Methods Linked English national Hospital Episode Statistics and mortality data (1999–2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk was estimated using Cox regression models. Individuals with a coded diagnosis of cerebrovascular disease, vascular parkinsonism, drug-induced parkinsonism, and normal pressure hydrocephalus were excluded from the analysis.

Results A total of 2,017,115 individuals entered the T2DM cohort and 6,173,208 entered the reference cohort. There were significantly elevated rates of PD following T2DM (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.29–1.35; < 0.001). The relative increase was greater in those with complicated T2DM (HR 1.49, 95% CI 1.42–1.56) and when comparing younger individuals (HR 3.81, 95% CI 2.84–5.11 in age group 25–44 years).

Conclusions We report an increased rate of subsequent PD following T2DM in this large cohort study. These findings may reflect shared genetic predisposition and/or disrupted shared pathogenic pathways with potential clinical and therapeutic implications.

Footnotes

* These authors contributed equally to this work.

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